A case Keith Morrison can't forget in which a teen's murder shakes a Nevada community and two unlikely people confess.

When a police officer's wife is shot to death in her bed, her parents' certainty that investigators have it wrong and their determination to untangle the mystery, makes the case unforgettable for Josh Mankiewicz.

Andrea Canning recalls a case in which investigators set up an elaborate sting operation to stop a murder-for-hire plot.

A man charged with murder claims it was impossible for him to have committed the crime. For Dennis Murphy, the surprising courtroom strategy provides a memorable twist.

Keith Morrison reflects on the case of a Chicago woman from a big family who went missing. Investigators began to suspect a man in her life was full of secrets.

Josh Mankiewicz recalls the story of a detective who makes it her mission to find dozens of women who vanished on the streets of Albuquerque, N.M.

Andrea Canning recalls the case of a popular kindergarten teacher who goes missing after shedding hundreds of pounds, and investigators find a link between her weight loss and her disappearance.

Dennis Murphy looks back at the story of a determined young woman whose decades-long search for answers in her mother's mysterious death leads to a dramatic courtroom decision.

Investigators track down a suspect in the disappearance of a celebrity dog trainer. Keith Morrison reflects on the fractured love story at the centre of this mystery.

A wife calls 911 to report her husband has been shot on a country road in Texas; what she tells investigators next makes this case memorable for Josh Mankiewicz.

Andrea Canning looks back on one of her most memorable cases where a fitness tracker helps detectives solve the mystery of a young woman's death in Wisconsin. Andrea confronts the killer in a tense interview.

When a star athlete at an Ivy League university goes on trial for murder, sparks fly in the courtroom; the trial ends with a stunning decision that Dennis Murphy will never forget, but the surprises in the case are just beginning.