We meet the first responder paramedics team from San Francisco City Hospital. They rescue by land, by sea or by air to reach and save to their victims in time. In this episode, tragedy hits close to home, and the lives and paths of each member of the team are forever changed.

Lives hang in the balance when a car crashes into a local street fair. Nancy is assigned to a new partner, while Rabbit teaches Marisa a lesson.

Boone's marital problems come second when an arm man starts to shoot in a rampage at an office. This problem forces Rabbit and Nancy to work together for the first time in over a year, with a injured hostages. Meanwhile, Marisa learns that she's more similar to Rabbit than she thought.

Tyler and Boone are called following an explosion at a Chinese restaurant. Meanwhile, Nancy's training is put to the test, and Rabbit reacts to a bumpy flight.

Tyler and Boone are on the scene when chaos erupts at a Halloween party. Meanwhile, Nancy and Glenn’s shift takes an unusual turn. Elsewhere, a secret is revealed that can change a partnership.

The tables are turned as Nancy and Glenn find themselves on opposing sides of a trauma. Elsewhere, the on-scene priorities of Boone are questioned, and Rabbit has a surprising reaction while treating a patient.

Glenn risks everything to follow his heart's desire. Rabbit helps a patient cope with a tragic loss. And an old friend surprises Marisa.

The team responds to a chaotic accident involving a wedding at sea and a speedboat collision. Elsewhere, Nancy takes a break from her hectic schedule to bond with her family.

Thanksgiving travel is halted when an airliner is forced to make an emergency landing, causing the entire team to be deployed to deal with the situation.

As a bad batch of heroin hits the streets of San Francisco, Glenn questions Nancy's judgment during an encounter with a "frequent flyer." Meanwhile, a bizarre theft sends Marisa on wild goose chase. Elsewhere, Boone contemplates his future and takes a new step, while a romance begins to take off.

Nancy's claustrophobia puts her patient at risk while Rabbit assists an injured bank robber.

Glenn handles a procedure by the book and loses a patient, bringing the whole station under a "probie curse." Meanwhile, Rabbit's suspension leads him to mandatory therapy sessions to regain his wings as his relationship with Nancy intensifies. Elsewhere, Marisa deals with a new partner, while Boone and Tyler have a patient jump out of the rig.

Rabbit has a breakthrough in therapy that reveals a traumatic event from his past. Meanwhile, Nancy and Dianas difference of opinion puts a patients life at risk. Elsewhere, Tyler and Boone consider their futures, as Glenn reaches a career milestone.

Nancy and Glenn get caught in the crossfire as a sniper takes San Francisco hostage. Rabbit and Marisa are torn between instinct and protocol as each emergency medical call could be a trap. Meanwhile, Boone must learn to adapt to Tyler's new paramedic status and medical knowledge.

Nancy comes under fire for ignoring protocol when treating a high school cheerleader and her actions put Dr. Joe in the hot seat and their relationship on the line. Meanwhile, Rabbit and Marisa are quarantined after being exposed to a patient with meningitis. Elsewhere, a misunderstanding puts Boone's partnership with Tyler to the test.

A patient who regularly abuses the system calls again for help. Nancy has problems with her father's new job and Boone disagrees with Tyler on how to treat a patient at a mosque. Also, a dream unsettles Marisa at work.

In the process of gathering stories for his book, Glenn finds himself discussing unusual calls with his work mates and ends up hearing much more than he imagined. Elsewhere, Tyler's dad comes to town for a visit.

Communications breakdown throws everyone into chaos and scrambling to the wrong locations.