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Sherlock Holmes is awakened in modern times with a tale that he had invented a method of suspended animation that he had utilized on himself. Awakened by an earthquake, he is helped by Amy Winslow, who lives at 1994 Baker Street in San Francisco. There he is joined by a new group of Baker Street Irregulars led by Zapper. His battles lead him to the evil Moriarty clan led by James Moriarty Booth.
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Sherlock Holmes is as dashing as ever, but with a little secret: Dr. Watson is the brains behind the operation. When Reginald Kincaid, the actor he has hired to play Holmes becomes insufferable, Watson fires him and tries to go out on his own, but finds that he has done too good a job building Holmes up in the public's mind.
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